Publications by authors named "R H F Valverde"

Bell pepper endornavirus (BPEV) Alphaendornavirus capsici (Endornaviridae) is an RNA virus that infects many pepper (Capsicum annuum) horticultural types and is seed transmitted. BPEV does not cause apparent symptoms and is found at every plant developmental stage. During the domestication of bell pepper, plant breeders, unaware of the existence of endornaviruses in the germplasm, selected endornavirus-infected genotypes.

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In this study, we completely sequenced the genome of a new member of the genus Alphaendornavirus, family Endornaviridae, from lima bean (Phaseolus lunatus), for which we propose the name "lima bean endornavirus 1" (LbEV1). The complete genome of LbEV1 consists of 15,265 nucleotides, including a stretch of 12 cytosine residues at its 3' end, and contains a long single open reading frame (ORF) coding for a 4980-aa-long polyprotein. Analysis of the polyprotein sequence revealed the presence of four conserved functional domains (in order from the N- to C-terminus): viral helicase 1, peptidase _C97, glycosyltransferase_GTB-type, and viral RNA-dependent RNA polymerase (RdRP).

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Article Synopsis
  • * Understanding the underlying mechanisms of AKI is crucial for developing effective treatments, particularly focusing on cell rescue and paracrine factors that aid in tissue repair.
  • * In this study, sphingosine 1-phosphate (S1P) was found to significantly enhance cell survival and proliferation in kidney proximal tubule cells after I/R injury, demonstrating its potential in promoting tissue repair via specific signaling pathways, including the SAFE and JAK2/STAT3 pathways.
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Purpose: The clinical outcomes of kidney transplantation from deceased donors have seen significant improvements with the use of machine perfusion (MP), now a standard practice in transplant centers. However, the use of perfusate biomarkers for assessing organ quality remains a subject of debate. Despite this, some centers incorporate them into their decision-making process for donor kidney acceptance.

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  • Basilar artery dolichoectasia (BADE) is an abnormal enlargement or displacement of the basilar artery, with a reported prevalence of 0.3 to 33.1% in stroke patients, but this may vary across different populations.
  • A study in Spain found that 34.1% of 126 patients aged 50 or older with acute ischemic stroke (AIS) or transient ischemic attack (TIA) exhibited BADE, with its prevalence linked to advanced age.
  • The study also noted that those with a fetal-type circle of Willis had smaller basilar artery diameters, while patients with lacunar strokes presented greater diameters compared to other stroke types.
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