Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice. While target mutations are well recognized as the basis of genetic resistance to targeted therapy, nontarget mutation resistance (or nongenetic resistance) remains poorly characterized. Despite its complex and unintegrated mechanisms in the literature, nongenetic resistance is considered from our perspective to be a collective response of innate or acquired resistant subpopulations in heterogeneous tumors to therapy.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
The Ni-rich LiNiCoMnO cathode (NCM, ≥ 0.6) suffers rapid capacity decay due to serious surface degradations from the corrosion of the electrolyte. The processes of the HO- and O-based AlO atomic layer deposition (ALD) on the single-crystal LiNiCoMnO (NCM83) are investigated by measurements to understand the mechanism of their different impacts on the electrochemical performance of NCM83.
View Article and Find Full Text PDFIntroduction: Musical instrument recognition is a critical component of music information retrieval (MIR), aimed at identifying and classifying instruments from audio recordings. This task poses significant challenges due to the complexity and variability of musical signals.
Methods: In this study, we employed convolutional neural networks (CNNs) to analyze the contributions of various spectrogram representations-STFT, Log-Mel, MFCC, Chroma, Spectral Contrast, and Tonnetz-to the classification of ten different musical instruments.
Introduction: Accurate diagnosis of the water status of fruit trees is a prerequisite for precise irrigation. Measurement of leaf turgor pressure provides a means to explore the water utilization mechanisms of fruit trees and their responses to water stress. However, there are few studies on the use of daily minimum leaf turgor pressure (Ppmax) to indicate water information in apple tree.
View Article and Find Full Text PDFZhonghua Kou Qiang Yi Xue Za Zhi
January 2025
Artificial intelligence (AI) technology is a scientific and technological field that focuses on the research and development of systems that simulate, extend, and expand human intelligence activities. This field encompasses various applications such as image recognition, language processing, expert systems, and robotics. The advancement of AI has greatly improved the quality and efficiency of medical work, particularly in areas like medical imaging, clinical decision support, precision medicine, and healthcare management.
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