Morphological Control of Y6 Thin Films Reveals Charge Transfer Is Facilitated by Co-facial Interactions.

The organic semiconductor Y6 has been extensively used as an acceptor in organic photovoltaic devices, yielding high efficiencies. Its unique properties include a high refractive index, intrinsic exciton dissociation, and barrierless charge generation in bulk heterojunctions. However, the direct impact of the crystal packing morphology on the photophysics of Y6 has remained elusive, hindering further development of heterojunction and homojunction devices.

Humanized dual-targeting antibody-drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity.

Cancer heterogeneity, characterized by diverse populations of tumorigenic cells, involves the occurrence of differential phenotypes with variable expressions of receptor tyrosine kinases. Aberrant expressions of mesenchymal-epithelial transition (MET) and recepteur d'origine nantais (RON) receptors contribute to the phenotypic heterogeneity of cancer cells, which poses a major therapeutic challenge. This study aims to develop a dual-targeting antibody-drug conjugate (ADC) that can act against both MET and RON for treating cancers with high phenotypic heterogeneity.

Simulation of Solvatochromic Phenomena in Xanthione Using Explicit Solvent Methods.

Xanthione is a sulfated polycyclic aromatic hydrocarbon which exhibits unique anti-Kasha properties and substantial sensitivity to its medium. Due to this sensitivity however, this makes xanthione-based systems very difficult to simulate. Further, xanthione's is understood to be come more photostable in the presence of a highly polar medium, however whether these photophysical properties could be taken advantage of for certain applications remains to be seen.

Small molecule-based regulation of gene expression in human astrocytes switching on and off the G-quadruplex control systems.

A great deal of attention is being paid to strategies seeking to uncover the biology of the four-stranded nucleic acid structure G-quadruplex (G4) via their stabilization in cells with G4-specific ligands. The conventional definition of chemical biology implies that a complete assessment of G4 biology can only be achieved by implementing a complementary approach involving the destabilization of cellular G4s by ad hoc molecular effectors. We report here on an unprecedented comparison of the cellular consequences of G4 chemical stabilization by pyridostatin (PDS) and destabilization by phenylpyrrolocytosine (PhpC) at both transcriptome- and proteome-wide scales in patient-derived primary human astrocytes.

Breaking the blue barrier of nucleobase fluorescence emission with dicyanovinyl-based uracil molecular rotor probes.

Dicyanovinyl-modified uracil produces fluorescent molecular rotors (FMR) that display massively red-shifted emission and huge Stokes shifts. They are exemplified by DCVSU - an intrinsically fluorescent nucleobase analog (IFNA) with the longest emission wavelength of 592 nm (DMSO) reported thus far which also shows strong polarity sensitivity and large Stokes shift ( = 181 nm). The IFNAs exhibited typical molecular rotor response to solvent viscosity with brightnesses ( × ) of up to 8700 cm M.