Publications by authors named "R Gurski"
Significant and distinct impacts of sleeve gastrectomy and Roux-en-Y gastric bypass on esophageal acid exposure, esophageal motility, and endoscopic findings: a systematic review and meta-analysis.
J Gastrointest Surg
September 2024
Background: The lack of standardized objective assessment of esophageal physiology and anatomy contributes to controversies regarding the effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on gastroesophageal reflux disease. This study aimed to investigate esophageal acid exposure, esophageal motility, and endoscopic findings before and after SG and RYGB.
Methods: This was a systematic review and meta-analysis of studies reporting at least 1 objective measure of esophageal physiology and/or esophagogastroduodenoscopy (EGD) at baseline and after SG or RYGB.
To evaluate the effect of dietary interventions aimed at weight loss in gastroesophageal reflux disease (GERD) symptoms and general health-related quality of life (HRQL) in overweight and obese patients. A population of GERD patients were randomized into two groups: the intervention group received individualized dietary counselling on scheduled appointments throughout 6 months of follow-up (n = 31) and the control group received only informative dietary guidelines on baseline (n = 31). Anthropometric data were monthly collected, and the HRQL score for GERD (GERD-HRQL) and the Health Survey (SF-36) questionnaires were applied on baseline and reevaluated at the end of follow-up.
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- Barrett's esophagus (BE) is a precursor to esophageal adenocarcinomas (EACs), but the mechanisms driving this transformation are not fully understood, prompting researchers to use an AI-driven approach for insight.
- The study validated its predictions through various methods including human organoid models and genomic analyses, concluding that EACs derive exclusively from BE and identifying a specific immune environment involving CXCL8/IL8 and neutrophils as a key factor in this transformation.
- Notably, this immune response is stronger in White individuals compared to African Americans, with findings suggesting that benign ethnic neutropenia (BEN) in Africans Americans might reduce the risk of progression from BE to EAC.
Echoendoscopy in Preoperative Evaluation of Esophageal Adenocarcinoma and Gastroesophageal Junction: Systematic Review and Meta-analysis.
Ultrasound Med Biol
July 2021
Esophageal adenocarcinomas of the esophagus and esophagogastric junction constitute a global health problem, the incidence of which has increased in recent decades. It has a poor prognosis and a low 5-year survival rate. Its treatment is based on preoperative clinical staging, in which echoendoscopy plays an essential role.
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