The DNA Damage Repair Function of Fission Yeast CK1 Involves Targeting Arp8, a Subunit of the INO80 Chromatin Remodeling Complex.

The CK1 family are conserved serine/threonine kinases with numerous substrates and cellular functions. The fission yeast CK1 orthologues Hhp1 and Hhp2 were first characterized as regulators of DNA repair, but the mechanism(s) by which CK1 activity promotes DNA repair had not been investigated. Here, we found that deleting Hhp1 and Hhp2 or inhibiting CK1 catalytic activities in yeast or in human cells increased double-strand breaks (DSBs).

Testing the predictions of reinforcement: long-term empirical data from a damselfly mottled hybrid zone.

Theoretical work suggests that reinforcement can cause the strengthening of prezygotic isolation in sympatry by mitigating the costs of maladaptive hybridization. However, only a handful of studies have simultaneously tested multiple predictions of this theory in natural populations. We investigated reinforcement in a mottled hybrid zone between the damselflies Ischnura elegans and I.

TITIRITIANDO: Creating an engaging theatrical education program to teach children that cotton-top tamarins (Saguinus oedipus) are not pets.

Cotton-top tamarins (Saguinus oedipus) are a critically endangered primate found only in Colombia. Proyecto Tití has been leading conservation efforts in Colombia and has developed successful conservation education programs that engage communities in activities that promote the long-term survival of cotton-top tamarins. TITIRITIANDO is an educational theatrical program that introduces children to cotton-top tamarins and the challenges they face in the illegal pet trade.

Validation of the Spanish Version of the Breakthrough Pain Assessment Tool in Patients With Cancer.

Introduction And Background: Assessment of breakthrough pain is essential for adequate management of cancer pain. The Breakthrough Pain Assessment Tool (BAT) has been proven to be a brief, multidimensional, and reliable questionnaire for the assessment of breakthrough cancer pain (BTCP). Currently, there are no validated instruments in Spanish that allow assessing BTCP.

A Multi-Country Survey on the Availability of Intraoperative Use of Echocardiography for Noncardiac Surgery.

Background: This survey aimed to explore the availability and accessibility of echocardiography during noncardiac surgery worldwide.

Methods: An internet-based 45-item survey was sent, followed by reminders from August 30, 2021, to August 20, 2022.

Results: 1189 responses were received from 62 countries.