Publications by authors named "R Guilbaud"
Background: Advances in high-throughput sequencing (HTS) technologies and reductions in sequencing costs have revolutionised the study of genomics and molecular biology by making whole-genome sequencing (WGS) accessible to many laboratories. However, the analysis of WGS data requires significant computational effort, which is the major drawback in implementing WGS as a routine laboratory technique.
Objective: Automated pipelines have been developed to overcome this issue, but they do not exist for all organisms.
Numerous SARS-CoV-2 variants are emerging as the epidemic continues, inducing new waves of contamination. In July 2023, a new variant named BA.2.
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- Immunocompromised individuals tend to experience longer SARS-CoV-2 infections, increasing the chances for new mutations, especially in the spike protein, which is important for vaccines.
- A study in Paris analyzed samples from 444 immunocompromised patients and 234 healthcare workers, finding greater genetic diversity of the virus in the immunocompromised group.
- The research indicated that mutations in the viruses from immunocompromised patients contributed to the evolution of new variants, suggesting potential concerns for immune response and severity of future infections.
Gene therapy, cell therapy and vaccine research have led to an increased use of qPCR/ddPCR in bioanalytical laboratories. CROs are progressively undertaking the development and validation of qPCR and ddPCR assays. Currently, however, there is limited regulatory guidance for the use of qPCR and a complete lack of any regulatory guidelines for the use of the newer ddPCR to support regulated bioanalysis.
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