Publications by authors named "R Guida"

The NA62 experiment at CERN, configured in beam-dump mode, has searched for dark photon decays in flight to electron-positron pairs using a sample of 1.4×10^{17} protons on dump collected in 2021. No evidence for a dark photon signal is observed.

View Article and Find Full Text PDF

Purpose: To address the clinical need for totally implantable mechanical circulatory support devices, Bionet Sonar is developing a novel Ultrasonic Transcutaneous Energy Transmission (UTET) system that is designed to eliminate external power and/or data communication drivelines.

Methods: UTET systems were designed, fabricated, and pre-clinically tested using a non-clinical HeartWare HVAD in static and dynamic mock flow loop and acute animal models over a range of pump speeds (1800, 2400, 3000 RPM) and tissue analogue thicknesses (5, 10, 15 mm).

Results: The prototypes demonstrated feasibility as evidenced by meeting/exceeding function, operation, and performance metrics with no system failures, including achieving receiver (harvested) power exceeding HVAD power requirements and data communication rates of 10kB/s and pump speed control (> 95% sensitivity and specificity) for all experimental test conditions, and within healthy tissue temperature range with no acute tissue damage.

View Article and Find Full Text PDF

Objectives: This study aimed to indicate the feasibility of a prototype electrical neuromodulation system using a closed-loop energy-efficient ultrasound-based mechanism for communication, data transmission, and recharging.

Materials And Methods: Closed-loop deep brain stimulation (DBS) prototypes were designed and fabricated with ultrasonic wideband (UsWB) communication technology and miniaturized custom electronics. Two devices were implanted short term in anesthetized Göttingen minipigs (N = 2).

View Article and Find Full Text PDF
Article Synopsis
  • - Rheumatic musculoskeletal diseases (RMD), like rheumatoid arthritis and spondyloarthritis, lack predictive biomarkers for effective treatment, making personalized care challenging for first-time patients.
  • - The introduction of anti-TNF biosimilars, which are cheaper alternatives to original drugs with similar efficacy and safety, has prompted the need for updated treatment guidelines.
  • - A group of rheumatologists in Campania, Italy, utilized a Delphi technique to create a therapeutic algorithm to standardize treatment approaches for RMD, considering clinical presentation, demographics, and comorbidities through discussion and consensus voting.
View Article and Find Full Text PDF

Bacterial extracellular membrane vesicles (EMVs) play an active role in many physiological and pathogenic processes. Here, we report the identification and the detailed structural characterization of the capsular polysaccharide from both cells and EMVs from Shewanella vesiculosa by NMR and chemical analysis. The polysaccharide consists of a pentasaccharide repeating unit containing neutral monosaccharides together with amino sugars, of which one has never been isolated from a natural source.

View Article and Find Full Text PDF