Application Discrepancies in the 2023-2024 Integrated Plastic Surgery Match.

Background: The Plastic Surgery Common Application (PSCA) was introduced in the 2020-2021 integrated plastic surgery match cycle. We investigated the accuracy of medical student-reported quantitative metrics in the PSCA.

Methods: Quantifiable data from 1 year of PSCA applications were compared between matched and unmatched students.

"Plastic Surgery Program Leadership Perspectives on Wellness and Professional Development Curricula-Where are we Now?".

Background: Burnout is common amongst surgical trainees and its consequences can be detrimental to both mental health and patient care. As such, wellness and professional development have moved to the forefront of discussion in surgical education. The purpose of this study is to describe the current landscape of wellness and professional development education, as well as barriers to initiation of dedicated curricula.

Beyond IQ: executive function deficits and their relation to functional, clinical, and neuroimaging outcomes in 3q29 deletion syndrome.

Background: 3q29 deletion syndrome (3q29del) is a rare (~1:30 000) genomic disorder associated with a wide array of neurodevelopmental and psychiatric phenotypes. Prior work by our team identified clinically significant executive function (EF) deficits in 47% of individuals with 3q29del; however, the nuances of EF in this population have not been described.

Methods: We used the Behavior Rating Inventory of Executive Function (BRIEF) to perform the first in-depth assessment of real-world EF in a cohort of 32 individuals with 3q29del (62.

Morphomolecular Pathology and Genomic Insights into the Cells of Origin of Cholangiocarcinoma and Combined Hepatocellular-Cholangiocarcinoma.

Cholangiocarcinomas are a highly heterogeneous group of malignancies that, despite recent progress in the understanding of their molecular pathogenesis and clinical management, continue to pose a major challenge to public health. The traditional view posits that cholangiocarcinomas derive from the neoplastic transformation of cholangiocytes lining the biliary tree. However, increasing genetic and experimental evidence has recently pointed to a more complex, and nuanced, scenario for the potential cell of origin of cholangiocarcinomas.

Global protein turnover quantification in Escherichia coli reveals cytoplasmic recycling under nitrogen limitation.

Protein turnover is critical for proteostasis, but turnover quantification is challenging, and even in well-studied E. coli, proteome-wide measurements remain scarce. Here, we quantify the turnover rates of ~3200 E.