Publications by authors named "R Greenstein"
Article Synopsis
- - The study examined genomic alterations in non-small cell lung cancer (NSCLC) across a large sample of over 75,000 patients in the US and compared findings with a Japanese cohort to identify differences based on race, sex, and age.
- - Significant variations in genetic alterations were observed: for example, EGFR mutations were more common in East Asian patients, while ALK mutations were prevalent in Admixed American, East Asian, and South Asian groups compared to others.
- - Additionally, the analysis showed clear distinctions in mutation prevalence linked to sex and age, with certain mutations like EGFR and ALK being more frequent in females, while mutations such as TP53 and KEAP1 were more common in males; older patients
Article Synopsis
- * A total of 794 patients were analyzed; key genetic alterations were found, particularly CDKN2A and TP53 in thymic carcinomas, with some differences in mutations observed between thymomas and thymic carcinomas.
- * Findings suggest a previously unrecognized potential for targeted treatments in TETs, highlighting new avenues for therapeutic development based on the genomic profiles discovered.
Article Synopsis
- Cornelia de Lange Syndrome (CdLS) is a rare genetic disorder marked by a variety of symptoms including growth delays, upper limb issues, and other systemic problems, primarily caused by mutations in specific genes associated with the cohesin complex.
- The majority of CdLS cases (over 60%) are linked to mutations in the NIPBL gene, which leads to the most severe form of the syndrome; other cohesin gene mutations typically result in milder symptoms.
- The study analyzed the genetic factors in 716 individuals with CdLS to better understand the contributions of cohesin complex genes and identify potential new candidate genes, improving knowledge of genetic variations and their effects on CdLS manifestations.
Hemorrhage from arteriovenous fistula sites is a known complication with potentially fatal consequences. The management of AV fistula hemorrhage has historically included direct pressure, tourniquet use, and/or surgical management. We describe a case of a 71-year-old female with hemorrhage from an AV fistula site that was successfully managed in the prehospital setting using a simple bottle cap.
View Article and Find Full Text PDFBackground: Selective tyrosine kinase inhibitors targeting fibroblast growth factor receptor (FGFR) 1-4 genomic alterations are in development or have been approved for FGFR-altered cancers (e.g. bladder cancer and advanced intrahepatic cholangiocarcinoma).
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