Publications by authors named "R Granata"
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peripheral tissues. Genetically engineered mice have been instrumental in elucidating the multifaceted roles of GHRH and GH, each offering unique insights into the physiological and pathological roles of these hormones, although in many of these models dissecting the direct effect of GHRH from the effect of GH is not possible. Key findings highlight the effects of GHRH deficiency on emotional behavior, including anxiety and depression, its impact on memory and learning capabilities, as well as on adipose tissue, immune system, inflammation and pain.
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- GHRH was discovered over 40 years ago and plays a key role in stimulating growth hormone production in the pituitary gland, but its functions have expanded to include various biological activities.
- Research indicates that GHRH and its analogues can influence multiple health issues, such as cell growth, immune functions, mood disorders, and several diseases, including diabetes and cancer.
- The promising results from laboratory studies suggest that GHRH agonists and antagonists could be developed into effective clinical treatments for various medical conditions.
Background: Hypoparathyroidism with hypocalcemia is the most frequent complication after thyroid surgery. Many risk factors have been involved in the development of this complication, with conflicting results. Incidental parathyroidectomy (IP) may be a frequent cause of postoperative hypocalcemia.
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