Isolation of a highly thermal stable lama single domain antibody specific for Staphylococcus aureus enterotoxin B.

Background: Camelids and sharks possess a unique subclass of antibodies comprised of only heavy chains. The antigen binding fragments of these unique antibodies can be cloned and expressed as single domain antibodies (sdAbs). The ability of these small antigen-binding molecules to refold after heating to achieve their original structure, as well as their diminutive size, makes them attractive candidates for diagnostic assays.

Co-design in synthetic biology: a system-level analysis of the development of an environmental sensing device.

The concept of co-design is common in engineering, where it is necessary, for example, to determine the optimal partitioning between hardware and software of the implementation of a system features. Here we propose to adapt co-design methodologies for synthetic biology. As a test case, we have designed an environmental sensing device that detects the presence of three chemicals, and returns an output only if at least two of the three chemicals are present.

Asbestos burden in cases of mesothelioma from individuals from various regions of the United States.

Mesothelioma is a rare tumor that is considered an asbestos marker disease. It occurs in individuals following a longer latency period from first exposure than other asbestos-related diseases. The tumor also occurs in individuals with a wide range of exposures, including individuals with lower level or secondary exposures.

Mood variability and the psychosocial adjustment of adolescents.

This research uses a new time sampling method to compare adolescent and adult mood variability. Over 9000 self-reports from 182 people are used to evaluate the widespread theoretical assumption that adolescents experience greater mood variability as part of a syndrome of psychosocial disequilibrium. The findings confirm that adolescents experience wider and quicker mood swings, but do not show that this variability is related to stress, lack of personal control, psychological maladjustment, or social maladjustment within individual teenagers.