Publications by authors named "R Goulabchand"
Importance: The Oral Rheumatoid Arthritis Trial Surveillance demonstrated an increased cancer risk among patients with rheumatoid arthritis (RA) taking tofacitinib compared with those taking tumor necrosis factor inhibitors (TNFis). Although international cohort studies have compared cancer outcomes between TNFis, non-TNFi drugs, and Janus kinase inhibitor (JAKis), their generalizability to US patients with RA is limited.
Objective: To assess the comparative safety of TNFis, non-TNFi drugs, and JAKis among US patients with RA (ie, the cancer risk associated with the use of these drugs among these patients).
Article Synopsis
- - The study investigated whether frailty status increases the risk of readmission in patients with rheumatoid arthritis (RA) using data from the 2018 Nationwide Readmissions Database.
- - Results showed that frail patients (48.1% of the sample) had significantly higher readmission rates (56.60% vs 30.61%), higher inpatient mortality (3.36% vs 0.39%), and longer hospital stays compared to non-frail patients.
- - On further analysis, frailty was linked to a 9% increased risk of readmission, highlighting the importance of identifying frail RA patients for better discharge planning and care.
Objective: The objective of this study was to evaluate the association between frailty status and risk of readmissions, inpatient death, and cost of admission among patients with systemic lupus erythematosus (SLE).
Methods: We conducted a retrospective cohort study using the National Readmissions Database. Using International Statistical Classification of Diseases, Tenth Revision codes, we identified individuals >18 years of age who had a primary or secondary diagnosis of SLE and were hospitalized between January and June 2018.
Article Synopsis
- - The study focused on examining the relationship between primary Sjögren's syndrome (pSS) and cancer, specifically analyzing the clinical, pathological, and immunological aspects of pSS patients who also had cancer, compared to those without cancer.
- - Out of 165 pSS patients, 55 had cancers, primarily solid neoplasms, with breast and lung cancers being the most common; significantly, many cancers were diagnosed close to or shortly after the pSS diagnosis.
- - Findings suggest that there may be a connection between breast cancers and pSS, implying that the immune system's behavior in pSS patients could play a role in cancer development or control.