Network-Based Drug Optimization toward the Treatment of Parkinson's Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation.

Parkinson's disease (PD), the second most common neurodegenerative disorder, affects around 10 million people worldwide. It is a multifactorial disease marked by dopaminergic neuron loss with oxidative stress (OS) and neuroinflammation as key pathological drivers. Current treatments focus on dopamine replacement and are symptomatic, underscoring the urgent need for disease-modifying therapies.

Ecophysiological responses to heat waves in the marine intertidal zone.

One notable consequence of climate change is an increase in the frequency, scale and severity of heat waves. Heat waves in terrestrial habitats (atmospheric heat waves, AHW) and marine habitats (marine heat waves, MHW) have received considerable attention as environmental forces that impact organisms, populations and whole ecosystems. Only one ecosystem, the intertidal zone, experiences both MHWs and AHWs.

Feeding sources of mosquitoes in Galapagos Islands: A potential threat to wildlife conservation.

Vector-borne diseases pose significant threats to both human and animal health, including wildlife, particularly in vulnerable island ecosystems like the Galapagos Islands. This study examines the mosquito community composition around domestic dogs and Galapagos sea lion rookeries across four islands: San Cristobal, Isabela, Santa Cruz, and Floreana. Using BG-Sentinel traps, a total of 292 mosquitoes were collected, identifying three species: Culex quinquefasciatus, Aedes aegypti, and A.

NEW OCCURRENCES OF PHYTOTELMATA-INHABITING MOSQUITOES SPECIES IN NORTHWESTERN ARGENTINA.

The potential risk areas for emerging or reemerging diseases are determined by the presence, abundance, and distribution of mosquitoes. Here new records and geographical distribution extension of mosquito species in phytotelmata are updated for Argentina. We report for the first time Toxorhynchites bambusicola in Aechmea distichantha in Salta and Tucumán provinces, in the northwest region of Argentina.

Feasibility study of hyperspectral colposcopy as a novel tool for detecting precancerous cervical lesions.

Cervical cancer remains a major global health concern, with a specially alarming incidence in younger women. Traditional detection techniques such as the Pap smear and colposcopy often lack sensitivity and specificity and are highly dependent on the experience of the gynaecologist. In response, this study proposes the use of Hyperspectral Imaging, a pioneering technology that combines traditional imaging with spectroscopy to provide detailed spatial and spectral information.