Publications by authors named "R Gokulnath"
Duchenne muscular dystrophy is a genetic disease produced by mutations in the dystrophin gene characterized by early onset muscle weakness leading to severe and irreversible disability. Muscle degeneration involves a complex interplay between multiple cell lineages spatially located within areas of damage, termed the degenerative niche, including inflammatory cells, satellite cells (SCs) and fibro-adipogenic precursor cells (FAPs). FAPs are mesenchymal stem cell which have a pivotal role in muscle homeostasis as they can either promote muscle regeneration or contribute to muscle degeneration by expanding fibrotic and fatty tissue.
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- - Duchenne muscular dystrophy (DMD) is a genetic disorder caused by mutations in the dystrophin gene, leading to early muscle weakness and severe disability, with unclear cellular mechanisms affecting potential therapies.
- - An analysis of muscle biopsies from young DMD patients revealed differences in cell populations, including more regenerative fibers and satellite cells, especially in younger patients, while older patients showed muscle fiber loss.
- - The study found a strong regenerative gene expression signature in DMD samples and highlighted fibro-adipogenic progenitor cells (FAPs) as important in cell signaling, indicating significant cellular and molecular changes in muscle tissues of DMD patients compared to healthy controls.
Fuzzy logic controller is developed for PV array fed interleaved dual buck-boost (IDBB) converter for EV battery charging applications. The inner dynamics of the IDBB converter is improved using the damping network. Irrespective of the change in solar insolation conditions, the developed fuzzy logic controller adjusts the duty ratio of the converter to obtain constant output voltage.
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