Publications by authors named "R Goggs"
Background: Comparative pharmacokinetics and pharmacodynamics (PK/PD) of apixaban and rivaroxaban have not been studied in dogs and the propensity of these drugs to cause hypercoagulability after discontinuation is unknown.
Hypothesis: Compare the PK/PD of clinical dosing regimens of PO apixaban and rivaroxaban administered repeatedly to healthy dogs and assess the effect of abrupt drug discontinuation on coagulation.
Animals: Six University-owned, purpose-bred, middle-aged, mixed-breed dogs (4 male, 2 female).
Plasma concentration of thrombopoietin in dogs with immune thrombocytopenia.
J Vet Intern Med
September 2024
Background: Immune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill-defined thrombopoietic response.
Objectives: Develop an immunoassay to measure plasma canine thrombopoietin (TPO) concentration and characterize TPO concentrations in dogs with pITP.
Article Synopsis
- Management of immune thrombocytopenia (ITP) in dogs and cats lacks established evidence-based guidelines, leaving treatment decisions largely to clinician discretion.
- The first-line treatment involves immunosuppressive glucocorticoids, with additional therapies such as azathioprine and vincristine used in more severe cases; however, optimal regimens are still unclear.
- A consensus process involving a structured literature review and expert opinions led to the creation of guidelines highlighting the need for further research in ITP treatment options.
Article Synopsis
- Immune thrombocytopenia (ITP) is a prevalent acquired disorder affecting the blood clotting process primarily in dogs and less frequently in cats, leading to significant health risks in both species.
- ITP can be classified into primary (autoimmune) and secondary (triggered by other diseases), but there is a lack of systematic evaluation regarding which underlying conditions trigger secondary ITP.
- A comprehensive study developed guidelines through a structured review of literature, expert input, and consensus-building processes to create diagnostic algorithms and screening recommendations for ITP in dogs and cats.