N-nitrososdimethylamine is activated in microsomes from hepatocytes to reactive metabolites which damage DNA of non-parenchymal cells in rat liver.

The liver carcinogen N-nitrosodimethylamine (NDMA) has to be metabolically activated by specific cytochromes before it can react with cellular macromolecules (e.g. proteins or DNA).

A rapid new method of measuring phagocytosis and cytotoxicity in macrophage tissue cultures.

111Indium as a radioactive tracer for labelling cells has advantages of 51 chromium: very low leakage after 24 h, superior counting properties of the radionuclide 111indium, and a labelling yield of greater than 70%. Tissue culture chamber slides combine the advantage of tissue culture micromethods with simple preparation techniques used in histology. We report here results with peritoneal macrophages as effector cells and erythrocytes and tumor cells as targets.