Publications by authors named "R Giniatullin"
Article Synopsis
- A new microscopic diagnostic sign for asphyxial drowning has been discovered in white male rats, indicating changes in the laryngeal mucosa.
- The research showed significant hyperplasia (increase in the number of cells) of serotonin-containing APUD-cells in the larynx when rats experienced acute anoxia, compared to healthy controls.
- These changes may trigger laryngospasm, which helps prevent water from entering the airways during drowning, suggesting this hyperplasia can be a useful diagnostic criterion in research on drowning.
Brain functionality relies on finely tuned regulation of gene expression by networks of non-coding RNAs (ncRNAs) such as the one composed by the circular RNA ciRS-7 (also known as CDR1as), the microRNA miR-7, and the long ncRNA Cyrano. We describe ischemia-induced alterations in the ncRNA network both in vitro and in vivo and in transgenic mice lacking ciRS-7 or miR-7. Our data show that cortical neurons downregulate ciRS-7 and Cyrano and upregulate miR-7 expression during ischemia.
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- Migraine is a severe neurological disorder characterized by heightened pain responses, and this review explores the role of mechanosensitive receptors in the pain pathways associated with migraines.
- A systematic analysis of 39 studies was conducted to evaluate various mechanosensitive receptors, including Piezo and K2P channels, and their involvement in migraine symptoms, primarily using animal models.
- The findings emphasize the complex interactions between these receptors and migraine pain, highlight potential gender differences in treatment strategies, and acknowledge challenges in developing effective drugs targeting these mechanisms.
Paclitaxel leads to peripheral neuropathy (paclitaxel-induced peripheral neuropathy [PIPN]) in approximately 50% of cancer patients. At present, there are no effective treatment strategies for PIPN, the mechanisms of which also remain unclear. In this study, we performed microbiome and metabolome analysis of feces and serum from breast cancer patients with different PIPN grades due to paclitaxel treatment.
View Article and Find Full Text PDFBackground: Engaging the endocannabinoid system through inhibition of monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), degrading endocannabinoids (endoCBs) 2-arachidonoylglycerol (2-AG) and anandamide (AEA), was proposed as a promising approach to ameliorate migraine pain. However, the activity of MAGL and FAAH and action of endoCB on spiking activity of meningeal afferents, from which migraine pain originates, has not been explored thus far. Therefore, we here explored the analgesic effects of endoCB enhancement in rat and human meningeal tissues.
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