Publications by authors named "R Giese"
Oral cancer is a major global health problem. It is commonly diagnosed at an advanced stage although often preceded by clinically visible oral mucosal lesions, termed oral potentially malignant disorders associated with an increased risk for oral cancer development. There is an unmet clinical need for effective screening tools to assist front-line healthcare providers to determine which patients should be referred to an oral cancer specialist for evaluation.
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- - The case describes a rare instance of head and neck metastasis stemming from a 53-year-old woman's prior colon mucinous adenocarcinoma, which typically spreads to the liver, lungs, or peritoneum.
- - She developed an isolated left cervical neck mass, accompanied by left eye symptoms, prompting diagnostic imaging and biopsy that confirmed the metastatic nature of the lesion.
- - This report underscores the need for awareness of unusual metastatic occurrences, the importance of early recognition in treatment planning, and calls for more research into effective treatment approaches for such rare cases.
Article Synopsis
- MITF (Microphthalmia-associated transcription factor) is crucial for melanocyte function and is linked to melanoma development, helping cancer cells survive therapy by regulating antioxidant responses.
- It promotes antioxidant programs that protect melanoma cells from damage caused by reactive oxygen species (ROS), with a clear association between MITF levels and antioxidant defenses in cell lines and patient samples.
- Experimental studies, including a zebrafish melanoma model, confirm that MITF reduces ROS-related DNA damage through direct regulation of specific target genes, establishing its role in enhancing cellular antioxidant capacity.
Drinking water security in Puerto Rico (PR) is increasingly challenged by both regulated and emerging anthropogenic contaminants, which was exacerbated by the Hurricane Maria (HM) due to impaired regional water cycle and damaged water infrastructure. Leveraging the NIEHS PROTECT (Puerto Rico Testsite for Exploring Contamination Threats) cohort, this study assessed the long-term tap water (TW) quality changes from March 2018 to November 2018 after HM in PR, by innovatively integrating two different effect-based quantitative toxicity assays with a targeted analysis of 200 organic and 22 inorganic pollutants. Post-hurricane PR TW quality showed recovery after >6-month period as indicated by the decreased number of contaminants showing elevated average concentrations relative to pre-hurricane samples, with significant difference of both chemical and toxicity levels between northern and southern PR.
View Article and Find Full Text PDFObjective In this study, we sought to identify the predictors for occult nodal disease (OND) and compare oncologic outcomes in patients undergoing elective neck dissection (END) at the time of salvage laryngectomy (SLE) versus the observation group. Methods A retrospective chart review was conducted involving all patients with clinically node-negative (cN0) necks who underwent SLE at a tertiary academic center over 12 years. A total of 58 patients met the inclusion criteria and were divided into two groups: END (n=39) and observation (n=19).
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