Trials
July 2022
Background: Irritable bowel syndrome (IBS) is a common functional bowel disorder that has a considerable impact on patient quality of life and substantial societal and health care resource costs. Current treatments are often ineffective. Tricyclic antidepressants have shown promise in secondary care populations but their effectiveness in a primary care setting remains unclear.
View Article and Find Full Text PDFAims: Determine the prevalence and severity of diabetic retinopathy (DR) and risk factors in a large community based screening programme, in order to accurately estimate the future burden of this specific and debilitating complication of diabetes.
Methods: A cross-sectional analysis of 91,393 persons with diabetes, 5003 type 1 diabetes and 86,390 type 2 diabetes, at their first screening by the community based National Diabetic Retinopathy Screening Service for Wales from 2005 to 2009. Image capture used 2×45° digital images per eye following mydriasis, classified by qualified retinal graders with final grading based on the worst eye.
Objectives: To determine the incidence of any and referable diabetic retinopathy in people with type 2 diabetes mellitus attending an annual screening service for retinopathy and whose first screening episode indicated no evidence of retinopathy.
Design: Retrospective four year analysis.
Setting: Screenings at the community based Diabetic Retinopathy Screening Service for Wales, United Kingdom.
Diabetes Technol Ther
April 2008
Background: This study evaluated the operating characteristics of a reading software (Retinalyze System, Retinalyze A/S, Hørsholm, Denmark) for automated prescreening of digital fundus images for diabetic retinopathy.
Methods: Digital fundus images of patients with diabetes were retrospectively selected from the Bro Taf diabetic retinopathy screening program in Wales, UK in the period of 2002-2004, which has been superseded by the Diabetic Retinopathy Screening Service for Wales. A gold standard reference was defined by classifying each patient as having or not having diabetic retinopathy based on overall visual grading of the digitized images using the Bro Taf reading protocol.
Sacral chordomas are rare, slow-growing tumours that are amenable to surgery, but unfortunately often diagnosed late. The aim of the study was to identify presenting symptoms, which may aid diagnosis and reduce the treatment time. Forty-four patients were identified with sacral chordoma between 1989 and 2006.
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