Nanosized quantum dots-wrapped metallic particles ensembles integrated into filter disc-based analytical device for garlic evaluation. Application to monitor fake pickled garlic in balsamic vinegar.

Herein, an affordable and simple analytical device is presented to portable identify of garlic in 30 min; the evaluation needs no pre-treatment of sample. The analytical device fabrication was did employing a headspace-based nanosensor array using of inexpensive materials as commercial filter discs, quantum dots (QDs), and metallic nanoparticles (MNPs). The nanoarray is fabricated by the accumulation QDs on MNPs surface, that results in the production of ensembles of QDs/MNPs.

Electrochemical-based remote biomarker monitoring: Toward Internet of Wearable Things in telemedicine.

Internet of Wearable Things (IoWT) will be a major breakthrough for remote medical monitoring. In this scenario, wearable biomarker sensors have been developing not only to diagnose point-of-care (POC) of diseases, but also to continuously manage them. On-body tracking of biomarkers in biofluids is regarded as a proper substitution of conventional biomarker sensors for dynamic sampling and analyzing due to their high sensitivity, conformability, and affordability, creating ever-rising the market demand for them.

Identifying SARS-CoV-2 main protease inhibitors by applying the computer screening of a large database of molecules.

The outbreak of coronavirus disease 2019 (COVID-19) at the end of 2019 affected global health. Its infection agent was called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Wearing a mask, maintaining social distance, and vaccination are effective ways to prevent infection of SARS-CoV-2, but none of them help infected people.

Optimization of Frizzled-8 Receptor Inhibition Activity of Carbamazepine: Designing New Anti-Cancer Agent.

Background: Frizzled-8 (FZD8) receptor is a therapeutic target for cancer treatment and recent research has shown that carbamazepine (CBZ) can inhibit this receptor.

Objective: In this work, it has been tried to optimize CBZ to enhance its binding capacity to the N6W binding site of FZD8 by using structure-based drug design methods.

Methods: CBZ and its 83 derivatives were docked to the N6W binding site of FZD8.

QSAR analysis on a large and diverse set of potent phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using MLR and ANN methods.

Phosphorylation of PI3Kγ as a member of lipid kinases-enzymes, plays a crucial role in regulating immune cells through the generation of intracellular signals. Deregulation of this pathway is involved in several tumors. In this research, diverse sets of potent and selective isoform-specific PI3Kγ inhibitors whose drug-likeness was confirmed based on Lipinski's rule of five were used in the modeling process.