Publications by authors named "R Genin"
Background: Severe leptospirosis occurs mainly in a tropical environment and includes icterus, acute renal failure and hemorrhages. These bleedings, which are mainly a consequence of acute homeostatic disturbances, can also reveal simultaneous diseases. Coinfections with other tropical diseases have been previously reported during leptospirosis.
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- This study examines post-transplantation lymphoproliferative disorder (PTLD) in kidney transplant recipients in France over a 10-year period, highlighting its serious impact on patient survival.
- A total of 500 cases of PTLD were analyzed, revealing a 5-year survival rate of 53% and a 10-year rate of 45%, with factors like age, serum creatinine level, and PTLD characteristics affecting survival.
- The researchers developed a prognostic score based on five variables at diagnosis to classify patients' risk levels, aiming to improve treatment strategies for PTLD in kidney transplant recipients.
Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized, multicenter trial.
Jacques Dantal François Berthoux Marie-Christine Moal Lionel Rostaing Christophe Legendre Robert Genin
Transpl Int
November 2010
Article Synopsis
- Immediate use of everolimus (mTOR inhibitor) post-kidney transplant can limit the need for calcineurin inhibitors while posing risks of delayed graft function (DGF) and impaired wound healing.
- The CALLISTO study involved 139 deceased-donor kidney transplant patients split into immediate (IE) and delayed (DE) everolimus groups, showing similar outcomes in primary endpoints after 12 months.
- Both groups had comparable rates of acute rejection and renal function, indicating no significant benefit in delaying everolimus initiation for patients at risk of DGF.
Article Synopsis
- There are concerns that starting sirolimus too soon after kidney transplantation may lead to delayed graft function (DGF) and wound healing issues, prompting the idea to delay everolimus administration instead.
- A study was conducted to assess the effects of starting everolimus immediately after transplantation versus delaying it for five weeks in patients at risk for DGF.
- The results showed no significant differences in kidney function recovery, wound healing, or overall treatment tolerance between the immediate and delayed everolimus groups at the 3-month mark.
Objective: Analysis of risk factors associated with severity in patients with confirmed leptospirosis.
Design And Setting: Retrospective study in 147 leptospirosis-confirmed patients at two tertiary nonteaching hospital in Reunion Island.
Patients: 138 men and 9 women, aged 36+/-14 years, 80 in the ICU and 67 in medical wards.