Publications by authors named "R Garrett Morgan"
Background: Children with sickle cell disease (SCD) have increased stroke risk, identifiable by elevated velocities on transcranial Doppler (TCD). This review assessed the impact of TCD screening on stroke, mortality, quality of life and morbidity in children with SCD.
Methods: A systematic search of MEDLINE, PubMed, Cochrane libraries, and trial registries was conducted from inception to 28th February 2023.
Background: Current Pediatric Advanced Life Support Guidelines recommend maintaining blood pressure (BP) above the 5th percentile for age following return of spontaneous circulation (ROSC) after cardiac arrest (CA). Emerging evidence suggests that targeting higher thresholds, such as the 10th or 25th percentiles, may improve neurologic outcomes. We aimed to evaluate the association between post-ROSC BP thresholds and neurologic outcome, hypothesizing that maintaining mean arterial pressure (MAP) and systolic blood pressure (SBP) above these thresholds would be associated with improved outcomes at hospital discharge.
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- * Diagnosis relies on cerebrospinal fluid analysis and neuroimaging techniques like MRI and SPECT, and there are recent advances in testing methods and imaging to monitor treatment effectiveness.
- * The main treatment is Penicillin G, while ceftriaxone is an alternative for those allergic to penicillin; both aim to improve patient outcomes by enhancing understanding of neurosyphilis pathophysiology and refining diagnostic and treatment methods.
Background: Detection of sickle cell disease (SCD) could be improved with greater use of point-of-care testing (POCT). This review assessed the accuracy of POCTs for SCD in children and adolescents.
Methods: We systematically searched EMBASE, PubMed, Cochrane libraries, registries and conference proceedings from inception to 28th February 2023.