Catatonia-related adverse outcomes after long-acting injectable antipsychotics: Case series.

Due to a lack of controlled, prospective trials examining the pathophysiology and treatment of catatonia, current guidelines vary regarding how and when to best use antipsychotics in the presence of catatonia and what factors to consider in a thorough risk-benefit analysis. The literature is especially limited in describing the risks and benefits of using long-acting injectable antipsychotics in the presence of catatonia. We describe four cases where patients with preexisting catatonia received long-acting injectable first generation antipsychotics and experienced severe adverse effects (three experienced worsening of catatonia and one experienced neuroleptic malignant syndrome).

Ventilation of the deep Gulf of Mexico and potential insights to the Atlantic Meridional Overturning Circulation.

Ventilation in the deep Gulf of Mexico (GoM), its connection to the North Atlantic, and its susceptibility to changes of the Atlantic Meridional Overturning Circulation are investigated by combining observations of radiocarbon and volume transport with a Coupled Model Intercomparison Project phase 6 (CMIP6) General Circulation Model (GCM) ensemble output. Radiocarbon data and multiannual volume transport through the Yucatan Channel suggest deep water residence times ~100 years for the GoM. Comparisons to previous radiocarbon observations suggest that the deep GoM has aged in the recent past, consistent with observed raising temperatures and the CMIP6 GCM simulations.

Psychosocial well-being among patients with malignant pleural mesothelioma.

Objectives: The investigators conducted a psychosocial needs assessment of mesothelioma patients through self-report measures of quality of life (QOL), coping, depression, and social support.

Methods: Patients with malignant pleural mesothelioma (MPM) ( = 67) completed a battery of assessments at a single timepoint after being approached during routine medical oncology clinic appointments or by letter.

Results: Participants were predominately male (70.

Targeting an Initiator Allergen Provides Durable and Expansive Protection against House Dust Mite Allergy.

Whereas treatment of allergic diseases such as asthma relies largely on the targeting of dysregulated effector pathways, the conceptually attractive alternative of preventing them by a pharmaceutical, at-source intervention has been stymied until now by uncertainties about suitable targets and the challenges facing drug design. House dust mites (HDMs) are globally significant triggers of allergy. Group 1 HDM allergens, exemplified by Der p 1, are cysteine proteases.