Publications by authors named "R Garcia-Rodas"
Article Synopsis
- Researchers are studying a type of yeast that can grow larger cells called "titan cells," which help it survive in hosts.
- They used old drugs and a special method to look at the size of these yeast cells to find which drugs stop them from getting big.
- They discovered that some of these drugs are antioxidants, showing that certain changes in the yeast's cells are important for making titan cells, and more research can help understand how these cells make the yeast stronger.
Article Synopsis
- Flippases in C. albicans, especially Drs2, are vital for lipid transport, maintaining membrane asymmetry, and enabling filamentous growth.
- Deleting drs2 not only makes the yeast susceptible to antifungals like fluconazole but also disrupts lipid distributions like PI(4)P and ergosterol.
- Manipulating other lipid transporters like Osh4 can partially compensate for Drs2's loss, but Drs2's role in membrane organization and localization is essential for resisting certain toxins and overall growth.
is a pathogenic yeast that can form Titan cells in the lungs, which are fungal cells of abnormally large size. The factors that regulate Titan cell formation in vivo are still unknown, although an increased proportion of these fungal cells of infected mice correlates with induction of Th2-type responses. Here, we focused on the role played by the cytokine IL-17 in the formation of cryptococcal Titan cells using knockout mice.
View Article and Find Full Text PDFPhosphatidylinositol phosphates are key phospholipids with a range of regulatory roles, including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI(4)P] at the Golgi apparatus is required for the budding-to-filamentous-growth transition in the human-pathogenic fungus Candida albicans; however, the role of plasma membrane PI(4)P is unclear. We have investigated the importance of this phospholipid in C.
View Article and Find Full Text PDFUnlabelled: In fungi, metals are associated with the expression of virulence factors. However, it is unclear whether the uptake of metals affects their pathogenicity. This study aimed to evaluate the effect of iron/copper in modulating pathogenicity and proteomic response in two clinical isolates of with high and low pathogenicity.
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