Implementation of a Pharmacokinetic Model for Inhaled Anesthetics Into a Software-Based Anesthesia Workstation for LLEAP-Compatible Simulators.

Introduction: Laerdal Learning Application (LLEAP)-compatible simulation manikins lack some specific functions that can be useful in anesthesia simulation scenarios. Our objective was to develop a software-based anesthesia workstation with a pharmacokinetic model for inhaled anesthetics for this simulation platform.

Methods: A Windows Presentation Foundation application that emulates an Aespire anesthesia workstation was created.

Risk Factors for Lymphatic and Hematogenous Dissemination in Patients With Stages I to II Cutaneous Melanoma.

Importance: The lymphatic and the hematogenous pathways have been proposed for disease progression in cutaneous melanoma, but association with recurrence has not been studied separately to date.

Objective: To identify the risk factors associated with lymphatic and hematogenous metastasis.

Design, Setting, And Participants: This retrospective cohort study included 1177 patients with malignant melanoma treated at Instituto Valenciano de Oncología, València, Spain.