Analysis of longitudinal patterns of child maltreatment reports in the United States.

Background: Child maltreatment is a continuous and prevalent issue, and victims of maltreatment often suffer adverse effects well into adulthood. Since child maltreatment rates tend to be clustered geographically and temporally, intervention programs are best implemented at a local level, targeting local risk factors for sustained and effective reduction over time.

Objective: Quantifying geographic variation in child maltreatment rate trajectories can help states identify local risk factors to guide program development and resource allocation.

Advancing cybersecurity and privacy with artificial intelligence: current trends and future research directions.

Introduction: The rapid escalation of cyber threats necessitates innovative strategies to enhance cybersecurity and privacy measures. Artificial Intelligence (AI) has emerged as a promising tool poised to enhance the effectiveness of cybersecurity strategies by offering advanced capabilities for intrusion detection, malware classification, and privacy preservation. However, this work addresses the significant lack of a comprehensive synthesis of AI's use in cybersecurity and privacy across the vast literature, aiming to identify existing gaps and guide further progress.

The ultrastructure of the starfish skeleton is correlated with mechanical stress.

Echinoderms and vertebrates both possess mesodermal endoskeletons. In vertebrates, the response to mechanical loads and the capacity to remodel the ultrastructure of the skeletal system are fundamental attributes of their endoskeleton. To determine whether these characteristics are also inherent in Echinoderms, we conducted a comprehensive biomechanical and morphological study on the endoskeleton of Asterias rubens, a representative model organism for Echinoderm skeletons.

Achieving Inclusion in Pharmacological Clinical Trials for Alzheimer's Disease.

Participant recruitment and retention into randomized controlled trials (RCTs) is a growing and evolving science. It varies dramatically by discipline given the important and key choices that must be made based on the unique trial design considerations. In the field of Alzheimer's Disease (AD) therapeutics, recruitment goals, approaches, and strategies vary based on the disease stage of the target population which can range from asymptomatic adults with biomarker evidence of the disease to end-stage symptom management.

Discovery of Dual Targeting GSK-3β/HIV-1 Reverse Transcriptase Inhibitors as Neuroprotective Antiviral Agents.

Glycogen synthase kinase-3 beta (GSK-3β or GSK-3B) is a serine-threonine kinase involved in various pathways and cellular processes. Alteration in GSK-3β activity is associated with several neurological diseases including Alzheimer's disease (AD), bipolar disorder, and rare diseases like Rett syndrome. GSK-3β is also implicated in HIV-associated dementia (HAD), as it is upregulated in HIV-1-infected cells and plays a role in neuronal dysfunction.