Publications by authors named "R Gallop"
Objective: Glycemic outcomes in youth with type 1 diabetes (T1D) in the United States using the two most common automated insulin delivery (AID) systems, Insulet Omnipod 5 (OP5) and Tandem Control IQ (CIQ), have not been compared. We performed the first head-to-head analysis of changes in glycemic metrics among youth initiating AID.
Methods: This single center, retrospective study included youth <21 years with T1D, who started OP5 or CIQ between 1/2020 and 12/2023, and had ≥70% CGM active time.
Background: Elexacaftor/tezacaftor/ivacaftor (ETI) is a highly effective therapy that improves lung disease in people with cystic fibrosis (pwCF), but its effect on glucose tolerance and insulin secretion is unclear.
Methods: PROMISE is a multicenter prospective, observational study of ETI in pwCF ≥12 years and at least one F508del allele. The PROMISE Endocrine sub-study (PROMISE-ENDO) enrolled participants at 10 CF Centers where hemoglobin A1c (HbA1c) was collected and 3-hour oral glucose tolerance tests (OGTT) conducted to examine glucose tolerance, glucose excursions, insulin secretory rates (deconvolution of C-peptide) and sensitivity (oral minimal model) prior to ETI and 12-18 months (mos) and 24-30 mos following ETI initiation.
Transplanted islet functional β-cell mass is measured by the β-cell secretory capacity derived from the acute insulin response to glucose-potentiated arginine (AIRpot), however, data are limited beyond one-year post-transplant for individuals with type 1 diabetes. We evaluated changes in β-cell secretory capacity in a single-center longitudinal analysis and examined relationships with measures of islet cell hormone metabolism and clinical measures of graft function (mixed-meal tolerance test [MMTT] C-peptide, BETA-2 score, and continuous glucose monitoring [CGM]). Eleven individuals received purified human pancreatic islets over one or two intra-portal infusions to achieve insulin-independence and were followed over a median (IQR) 6 (5-7) years.
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- The study aimed to assess the effectiveness of a school-based telehealth program, IPT-AST, for preventing depression in adolescents compared to standard services.
- A total of 242 adolescents with high depression scores participated and provided data at baseline, 2 months, and 3 months to evaluate changes in depression and anxiety symptoms.
- Results indicated that IPT-AST participants experienced significantly greater reductions in anxiety symptoms and were more engaged with the program, suggesting that telehealth interventions can be both feasible and beneficial for adolescent mental health.
Article Synopsis
- Poor prenatal sleep quality in mothers is linked to negative outcomes for both the mother and infant, including changes in brain development and increased anxiety-like behaviors.
- A study involving 116 mother-infant pairs used surveys to assess maternal sleep quality and MRI scans to examine neonatal brain development, specifically focusing on the uncinate fasciculus.
- Results showed that poorer maternal sleep during pregnancy correlated with higher levels of white matter in infants, which then related to greater infant negative emotionality, indicating that maternal sleep is an important environmental factor influencing child development.