Publications by authors named "R Gagliardini"
Objectives: The aim was to investigate whether switching from EFV/F/TDF to B/F/TAF may improve neuropsychiatrc symptoms and neurocognition.
Design: Pilot, single-arm, prospective study of persons with HIV (PWH) on the efficacy and safety of switching from EFV/F/TDF to B/F/TAF.
Methods: Participants underwent neuropsychological assessment (NPA) at switch (T0) and after 48 weeks (T1).
Article Synopsis
- The study analyzed HIV-1 sequences from 2386 drug-naïve individuals in Italy from 2015 to 2021 to assess the prevalence of transmitted drug resistance (TDR) among them.
- TDR prevalence was found to be 8%, with a slight difference between B subtypes (9.5%) and non-B subtypes (6.1%), and it remained stable over the years assessed.
- The research indicated that certain subtypes were associated with lower TDR rates, emphasizing the need for ongoing monitoring of TDR in newly diagnosed HIV patients to improve treatment strategies.
In a restricted subset of people living with HIV-1 (PLWH) on antiretroviral therapy (ART) with persistent suppressed viral load (i.e., -based HIV-RNA repeatedly undetected), a dual-target ( and ) diagnostic assay for HIV-RNA monitoring can measure quantifiable levels of viral loads (VL) above 30 copies/mL exclusively through the amplification of the region, while the target results undetected.
View Article and Find Full Text PDF