TS-1/spherical activated carbon composites in the epoxidation of methyl oleate.

One approach to increase the catalytic efficiency of TS-1 is the synthesis of TS-1 composite materials together with spherical activated carbon (SAC). Although increased Ti-site normalized catalytic activity of such composites compared to parent materials was observed, the reason for the increased activity is not fully understood. This study therefore aims to correlate the physico-chemical and catalytic activity of TS-1/SAC composites.

Genome sequences of three temperate actinobacteriophages from clusters FA and AS.

Three novel temperate siphoviruses, Juno112, KHumphrey, and ChuckDuck, were isolated from soil at Stevenson University using the bacterium B-2979. Based on gene content similarity, Juno112 and KHumphrey are assigned to actinobacteriophage cluster AS3 and ChuckDuck to cluster FA. All three phages encode tyrosine recombinases, with ChuckDuck encoding two.

A Meta-Analysis of the Safety and Immunogenicity of Pharmacokinetic Similarity Studies and Comparative Clinical Studies.

A biosimilar clinical development program generally includes a pharmacokinetic similarity study and a comparative clinical study. Since both types of studies assess safety and immunogenicity, it is important to evaluate the role of each in determining whether there are any meaningful differences between the proposed biosimilar products and the reference products. We conducted a systematic review and meta-analysis of the safety and immunogenicity data from pharmacokinetic similarity studies and comparative clinical studies, using a database of approved monoclonal antibody and fusion protein biosimilars.