Publications by authors named "R GADEA"
Purpose: This study aimed to assess the amount and types of clinical genetic testing denied by insurance and the rate of diagnostic and candidate genetic findings identified through research in patients who faced insurance denials.
Methods: Analysis consisted of review of insurance denials in 801 patients enrolled in a pediatric genomic research repository with either no previous genetic testing or previous negative genetic testing result identified through cross-referencing with insurance prior-authorizations in patient medical records. Patients and denials were also categorized by type of insurance coverage.
Article Synopsis
- The study focused on improving diagnosis and understanding of genetic disorders in children through the Genomic Answers for Kids program by analyzing genetic information from 960 families.
- Researchers utilized various sequencing methods, including short-read and long-read genome sequencing, alongside machine learning to prioritize genetic variants and stored the data in a structured database for future access.
- The results showed varying diagnostic success rates, with new diagnostic information gained from structural variants and long-read sequencing, highlighting ongoing challenges in identifying variants of unknown significance in nondiagnostic cases.
Article Synopsis
- Obesity is a growing public health issue, and this study focuses on hormonal changes in obese rats with type 2 diabetes after different types of weight-loss surgeries: sleeve gastrectomy (SG), gastric plication (GP), and sham operation (SO).
- After four weeks, rats in the SG and GP groups showed significant weight loss and lower fasting glucose levels compared to the control group, indicating the surgeries were effective in metabolic improvement.
- The study found that both ghrelin and leptin levels decreased while adiponectin levels increased post-surgery, suggesting a potential hormonal role in facilitating weight loss.
Chlorhexidine (CH) and quaternary ammonium compounds (QAC), such as cetrimide (CE), are widely used as disinfectants because of their broad antimicrobial spectrum. However, their frequent use for disinfection in different settings may promote bacterial drug resistance against both biocides and clinically relevant antibiotics. This study analyzes the effects of stepwise exposure to cetrimide (CE) and chlorhexidine (CH) of bacteria from organic foods and previously classified as biocide-sensitive.
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