Publications by authors named "R G Warner"
A 34-year-old male patient with recently diagnosed with medullary thyroid carcinoma underwent total thyroidectomy and radical neck dissection, requiring sharp dissection to separate the tumour from the trachea. He required post operative intubation due to bilateral vocal cord paralysis. He developed ischaemic necrosis of the upper two thirds of the trachea presenting with marked surgical emphysema and an infective wound.
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- * Hybrid products change the functional and nutritional properties based on the type of alternative protein used, and they can provide a balance of amino acids, enhancing their overall nutrition profile.
- * Despite the potential benefits of hybrid products, such as improved iron bioavailability, further research is needed to understand their digestibility, oxidative stability, and microbiological safety.
Objective: To evaluate the safety and efficacy of prednisone on pregnancy rates and semen concentrations at 1 year after vasectomy reversal.
Design: Randomized, controlled trial (NCT04788823).
Setting: Single medical center specializing in vasectomy reversals.
Serum activities of alanine- and aspartate aminotransferases (ALT and AST) are considered the "gold standard" biomarkers of hepatocyte injury in clinical practice and drug development. However, due to the expression of ALT and AST in myocytes, the diagnosis of hepatocellular injury in patients with underlying muscle diseases, including drug-induced muscle injury, is severely limited. Thus, we proposed glutamate dehydrogenase (GLDH) as a liver-specific alternative to serum ALT and AST.
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- The study explores gene therapy targeting L-cone opsin expression as a treatment for blue cone monochromacy (BCM), a condition caused by the lack of long- and middle-wavelength-sensitive cone function.
- Eight patients with BCM underwent various assessments, including optical coherence tomography and chromatic perimetry, revealing outer retinal changes and significant deficiencies in color vision and visual acuity.
- The research emphasizes the need for specialized outcome measures, such as dark-adapted microperimetry and specific visual acuity tests, to evaluate the efficacy and safety of potential future treatments in clinical trials.