Publications by authors named "R G Van Wijk"
Pyruvate kinase (PK), a key ATP-generating enzyme in glycolysis, is a target for novel sickle cell disease (SCD) therapies. Enhancing PK activity lowers 2,3-diphosphyglycerate (2,3-DPG), increases adenosine triphosphate (ATP), and may prevent red blood cell (RBC) sickling. Townes and Berkeley SCD mouse models are commonly used for the development of novel drugs for SCD, but differ from humans in 2,3-DPG and ATP levels, which could be related to underlying differences in PK properties.
View Article and Find Full Text PDFBackground: People with disabilities due to neglected tropical diseases (NTDs), such as leprosy and lymphatic filariasis (LF), often encounter situations of stigma and discrimination that significantly impact their mental wellbeing. Mental wellbeing services are often not available at the peripheral level in NTD-endemic countries, and there is a need for such services. Basic psychological support for persons with NTDs (BPS-N) from peers is an important potential solution for addressing mental wellbeing problems.
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- * Data from 1,661 patients at the University Medical Centre Groningen revealed variations in predictive accuracy depending on the infection site, with the NEWS and NEWS-2 performing best for abdominal infections.
- * The findings suggest that incorporating the source of infection into EWS development could improve prognostic tools for sepsis, advocating for more tailored approaches to enhance prediction accuracy.
Article Synopsis
- Hypothermic oxygenated perfusion (HOPE) is a new technique being tested to preserve donor hearts, showing positive early results in clinical trials.
- Unlike other organs, cardiac HOPE includes red blood cell (RBC) supplementation, even though there's limited evidence proving its effectiveness.
- While initial findings on RBC use during cardiac HOPE are encouraging, there may be drawbacks that need more research to enhance heart preservation methods.