Publications by authors named "R G Pleijhuis"

Article Synopsis
  • Angioedema can occur without hives as a serious complication of r-tPA treatments like alteplase and tenecteplase, potentially causing airway issues that may require intubation.
  • *Current guidelines recommend addressing this by targeting the histamine pathway, but the article argues it should actually be treated by focusing on the bradykinin pathway instead.
  • *The manuscript calls for an update to the American Heart Association/American Stroke Association guidelines to enhance the treatment of r-tPA-induced angioedema and prevent serious outcomes.
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Background: Postoperative pancreatic fistula is a frequent and potentially lethal complication after pancreatoduodenectomy. Several models have been developed to predict postoperative pancreatic fistula risk. This study was performed to evaluate the quality of reporting of postoperative pancreatic fistula prediction models after pancreatoduodenectomy using the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) checklist that provides guidelines on reporting prediction models to enhance transparency and to help in the decision-making regarding the implementation of the appropriate risk models into clinical practice.

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Background: Pancreatoduodenectomy (PD) is the only cure for periampullary and pancreatic cancer. It has morbidity rates of 40-60%, with severe complications in 30%. Prediction models to predict complications are crucial.

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Objectives: In a recent scoping review, we identified 43 mortality prediction models for critically ill patients. We aimed to assess the performances of these models through external validation.

Design: Multicenter study.

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