Publications by authors named "R G Panchal"
Loss of dopaminergic neurons in Parkinson's disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human postmortem tissue, we show that accumulation of α-syn micro-aggregates impairs metabolic flux through the pentose phosphate pathway (PPP).
View Article and Find Full Text PDFSolar collector systems efficiently transform sunlight into energy that may be used to meet various needs. This research aimed to use the Taguchi method to determine the ideal operating parameters for a solar thermal collector with a rectangular spiral absorber. Controllable parameters including mass flow rate, solar radiation, and absorber design were manipulated during the energy recovery process, and features like PV temperature and outlet water temperature were used to assess the system's effectiveness.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a predictive tool to determine which patients with mild traumatic brain injury (mTBI) and subdural hematoma (SDH) may need neurosurgical intervention, as current methods are unreliable and lead to unnecessary treatments.
- Conducted across six trauma centers, the research analyzed 1,333 patients admitted between 2016 and 2020, using variables like hematoma thickness and Glasgow Coma Scale scores to inform predictions.
- Results showed a neurosurgical intervention rate of 8.8%, with key factors identified for predicting surgical need while maintaining a sensitivity of 100%.
Article Synopsis
- - The study examined the differences in causes of undiagnosed pleural effusions between outpatient and inpatient settings, involving 1,080 adult patients from four UK hospitals.
- - Results showed that malignant effusions were more frequent in outpatients (48.3%) while infections were more common in inpatients (36.2%), indicating significant differences based on patient status.
- - The findings suggest that diagnostic approaches should be tailored based on whether patients are admitted to the hospital or seen as outpatients.
Article Synopsis
- Study Objective
- : The research evaluated the effectiveness of facemask sampling (FMS) to detect SARS-CoV-2 in vaccinated individuals during a mock PACES examination in Leicester, UK.
- Methodology and Results
- : Thirty-four participants wore modified facemasks capable of capturing exhaled virus and provided upper respiratory tract samples. Only one participant tested positive for SARS-CoV-2 via URTS, but not through FMS, indicating no transmission to others.
- Participant Feedback
- : Most participants found FMS acceptable, but 69% believed that a positive FMS result alone was not enough for a definitive diagnosis. The study suggests that FMS is a viable method for identifying infectious individuals