Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.

Sex hormone-binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta-analysis explores the potential of SHBG as a biomarker for predicting GH and PE.

Production and Purification of Pectinase from 15A-B92 and Its Biotechnological Applications.

Enzymes that degrade pectin are called pectinases. Pectinases of microbial origin are used in juice clarification as the process is cost-effective. This study screened a pectinase-producing bacterium isolated from soil and identified as 15A B-92 based on the 16S rRNA molecular technique.

Could Disease Severity and Inflammatory Markers (IL-6, Hs-CRP, TNF-α) be Related to Frailty in COPD? A Prospective Study.

Chronic Obstructive Pulmonary Disease (COPD) causes major morbidity and mortality worldwide. Various tools like ABCD assessment tool, COPD assessment tool (CAT) and mMRC dyspnea scale are employed to assess extent of disease progression and guide therapy. Since COPD involves chronic lung inflammation, serum levels of several inflammatory markers may relate to disease severity.

Endoplasmic reticulum stress: A master regulator of metabolic syndrome.

Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's physiological activity and coordinate the apoptotic and adaptive responses. Pathophysiological conditions that augment ER stress include hypoxia, misfolded and/or mutated protein accumulation, and high glucose.

Ethical and legal aspects of conducting clinical trials in alcohol withdrawal syndrome.

Alcohol Withdrawal Syndrome (AWS) is a condition where the patients will be mentally unstable initially and where later, with therapy, they gradually return to normalcy. As AWS comprises two stages; a mentally unstable state and a normal state of mind, the ethical and legal issues behind recruitment of these subjects become a little ambiguous in a clinical trial. This study was taken up to clarify the uncertainty regarding the biphasic states of minds (i.