Publications by authors named "R G O'Regan"
Objectives: Periprosthetic joint infection (PJI) is a complication of joint arthroplasty and is seen in 1-2% of cases. Since its initiation in 2013, the national outpatient parenteral antimicrobial therapy (OPAT) program has facilitated the outpatient management of intravenous antimicrobials for PJI. This study aims to describe the clinical epidemiology of patients on OPAT with PJI between 2013 and 2021.
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- The study examines the connection between breast cancer subtypes and CSF cytology results with overall survival among patients with leptomeningeal disease.
- Out of 69 participants, triple-negative breast cancer was linked to significantly shorter survival compared to ER+/HER2- subtype, while CSF- patients had better overall survival compared to those with positive or not tested CSF results.
- The findings highlight the importance of breast cancer subtypes and CSF cytology in determining patient prognosis, suggesting that specific subtypes could influence survival outcomes.
In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types.
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