Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3-Butanediol in Patients With Heart Failure With Reduced Ejection Fraction.

Background: Oral treatment with the exogenous ketone body 3-hydroxybutyrate improves cardiac function in patients with heart failure with reduced ejection fraction, but ketosis is limited to 3 to 4 hours. Treatment with (R)-1,3-butanediol (BD) provides prolonged ketosis in healthy controls, but the hemodynamic and metabolic profile is unexplored in patients with heart failure with reduced ejection fraction.

Methods And Results: This was a randomized, single-blind, placebo-controlled, crossover study.

Using Self-Reported Training Characteristics to Better Understand Who Is More Likely to Sustain Running-Related Injuries Than Others: The Garmin-RUNSAFE Running Health Study.

Running is a popular form of physical activity, yet it comes with risks, including running-related injuries (RRIs). This cohort study aimed to use self-reported baseline data on running experience, weekly running frequency, greatest running distance in 1 week, and running program to investigate if certain adult runners were more likely to sustain RRI than others. Runners, aged ≥ 18 years, familiar with the English language and using a Garmin watch to track their running were included.

Room-Temperature Deposition of δ-NiGa Thin Films and Nanoparticles via Magnetron Sputtering.

Magnetron sputtering is a versatile method for investigating model system catalysts thanks to its simplicity, reproducibility, and chemical-free synthesis process. It has recently emerged as a promising technique for synthesizing δ-NiGa thin films. Physically deposited thin films have significant potential to clarify certain aspects of catalysts by eliminating parameters such as particle size dependence, metal-support interactions, and the presence of surface ligands.