Publications by authors named "R G Melhem"
Patients requiring continuous mechanical ventilation benefit from easier airway management through tracheostomy, a standard treatment in critical care. However, gaps in nurses' comprehension of tracheostomy car can lead to complications such as infections and airway blockages. Therefore, understanding nurses' competency in tracheostomy care is essential for enhancing patient outcomes in intensive care units (ICUs).
View Article and Find Full Text PDFGlucokinase (GK) catalyses the key regulatory step in glucose-stimulated insulin secretion. Correspondingly, hetero- and homozygous mutations in human cause maturity-onset diabetes of the young (GCK-MODY) and permanent neonatal diabetes (PNDM), respectively. To explore the possible utility of glucokinase activators (GKA) and of glucagon-like receptor-1 (GLP-1) agonists in these diseases, we have developed a novel hypomorphic allele in mice encoding an aberrantly spliced mRNA deleted for exons 2 and 3.
View Article and Find Full Text PDFBackground: Brain ageing is highly heterogeneous, as it is driven by a variety of normal and neuropathological processes. These processes may differentially affect structural and functional brain ageing across individuals, with more pronounced ageing (older brain age) during midlife being indicative of later development of dementia. Here, we examined whether brain-ageing heterogeneity in unimpaired older adults related to neurodegeneration, different cognitive trajectories, genetic and amyloid-beta (Aβ) profiles, and to predicted progression to Alzheimer's disease (AD).
View Article and Find Full Text PDFAdvancements in Biologic Therapies for Eosinophilic Gastrointestinal Diseases: A Comprehensive Review.
Immunol Allergy Clin North Am
November 2024
Article Synopsis
- Eosinophilic gastrointestinal diseases (EGIDs) are disorders marked by an excess of eosinophils in the GI tract, causing symptoms like abdominal pain and difficulty swallowing.
- Effective treatments are being developed, focusing on monoclonal antibodies that target inflammatory responses related to eosinophils.
- Dupilumab is the only FDA-approved monoclonal antibody for treating eosinophilic esophagitis (EoE), and the article will explore various biologics used for managing EGIDs.
Objective: Professional values are crucial for delivering high-quality care in neonatal intensive care units while caring behavior impacts nurses' performance and well-being. The purpose of this study was to assess the relationship between professional values and caring behavior among nurses in neonatal intensive care units.
Methods: A cross-sectional study involving 172 nurses was conducted using the Nursing Professional Value Scale and Caring Behaviors Assessment Tool.