A multi-taxon analysis of European Red Lists reveals major threats to biodiversity.

Biodiversity loss is a major global challenge and minimizing extinction rates is the goal of several multilateral environmental agreements. Policy decisions require comprehensive, spatially explicit information on species' distributions and threats. We present an analysis of the conservation status of 14,669 European terrestrial, freshwater and marine species (ca.

Alarming decline of freshwater trigger species in western Mediterranean key biodiversity areas.

Theidentification of key biodiversity areas (KBA) was initiated by the International Union for Conservation of Nature in 2004 to overcome taxonomic biases in the selection of important areas for conservation, including freshwater ecosystems. Since then, several KBAs have been identified mainly based on the presence of trigger species (i.e.

William Orange CB, MD, FRCP, LSA: A Broadmoor pioneer.

William Orange was the second Medical Superintendent of Broadmoor and in the 23 years he spent there created a management style that was greatly admired. Among his patients were the painter Richard Dadd, the Surgeon of Crowthorne and the Brighton poisoner. As advisor to the Home Office he also made a significant contribution to the interface between medicine and the law.

Tricyclic HIV integrase inhibitors V. SAR studies on the benzyl moiety.

SAR studies on the para-fluorobenzyl moiety of tricyclic HIV integrase inhibitors are discussed and lead compounds with potency and PK properties comparable to raltegravir were identified.