Biomarkers.

Background: The TAR DNA-binding protein of 43 kDa (TDP-43) is linked to hippocampal volume loss and faster rates of hippocampal atrophy in Alzheimer's disease and primary age-related tauopathy (PART). Hence, TDP-43 is becoming an important player in age-related neurodegeneration. To advance our understanding of TDP-43 effect on hippocampus, we conducted an imaging-pathological study to determine which specific hippocampal subfields are affected by TDP-43 in cases of PART.

Biomarkers.

Background: Transactive response DNA-binding protein of 43 kDa (TDP-43) is implicated in numerous neurodegenerative diseases, including Alzheimer's disease (AD). Immunohistochemically stained TDP-43 is linked to faster rates of hippocampal atrophy (HA) in AD. However, it is unclear whether phosphorylated TDP-43 (pTDP-43) measured using an immunoassay is also associated with HA.

Alzheimer's Imaging Consortium.

Background: Transactive response DNA-binding protein of 43 kDa (TDP-43) is implicated in numerous neurodegenerative diseases, including Alzheimer's disease (AD). Immunohistochemically stained TDP-43 is linked to faster rates of hippocampal atrophy (HA) in AD. However, it is unclear whether phosphorylated TDP-43 (pTDP-43) measured using an immunoassay is also associated with HA.

Alzheimer's Imaging Consortium.

Background: The TAR DNA-binding protein of 43 kDa (TDP-43) is linked to hippocampal volume loss and faster rates of hippocampal atrophy in Alzheimer's disease and primary age-related tauopathy (PART). Hence, TDP-43 is becoming an important player in age-related neurodegeneration. To advance our understanding of TDP-43 effect on hippocampus, we conducted an imaging-pathological study to determine which specific hippocampal subfields are affected by TDP-43 in cases of PART.

New Eocene species of the crinoid genera Holopus and Cyathidium (Cyrtocrinida: Holopodidae) from north-eastern Italy.

Holopodidae is one of the three families in the order Cyrtocrinida that have extant representatives. Two genera have been described, Holopus and Cyathidium, both with extant species and fossil representatives dating back to the Cenomanian (Late Cretaceous). Eocene (Lutetian) holopodid material from the Chiampo Valley (north-eastern Italy) has recently been attributed to H.