Publications by authors named "R G Fedina"
In Wistar rats with transplanted Walker 256 carcinosarcoma a use of melatonin as monoagent causes changes in intracellular organization of endothelial cells: reduced volume density of mitochondria, granular cytoplasmic network, micropinocytic vesicles, reduced the number density of free and attached ribosomes, which leads to increased apoptosis of tumor cells of Walker 256 carcinosarcoma.
View Article and Find Full Text PDFWhole-body controlled hyperthermia (up to 43.5 degrees C) of Wistar rats with Walker-256 carcinosarcoma was followed by symptoms of enhanced lipid peroxidation for 3-14 days and release of lysosomal enzymes into blood on day 14. Our data, in totality, point to a potential to stimulate tumor cell apoptosis.
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- Benz(a)pyrene administration at 20 mg/kg significantly increased the excretion of lysosomal enzymes in rat bile without harming the lysosomes.
- Constant exposure to light altered liver cell function, enhancing lysosomal activity while suppressing regular bile enzyme release.
- When benz(a)pyrene treatment was combined with light exposure, it reduced the stimulatory effects on lysosomal enzyme transport to bile but didn't completely remove the impact.