Publications by authors named "R G Faragher"
Article Synopsis
- Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
- The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
- The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
Article Synopsis
- Tendinopathy is a common age-related condition affecting both human athletes and horses, with the equine superficial digital flexor tendon serving as an excellent model for studying human Achilles tendon injuries.
- Corticosteroids, like dexamethasone, can lead to steroid-induced senescence (SIS) in equine tenocytes, characterized by growth arrest and the upregulation of specific proteins and enzymes, complicating their clinical use.
- Preincubation with resveratrol or the SIRT1 activator SRT1720 can prevent SIS, suggesting potential new therapeutic strategies that may work through mechanisms not solely reliant on SIRT1 activation.
Progressive liver disease and dysfunction cause toxic metabolites including ammonia and unconjugated bilirubin to accumulate in plasma. As the population ages alternatives to liver transplantation become increasingly important. One approach for use as a bridge to transplant or recovery is the use of bioartificial liver systems (BALS) containing primary or immortalised hepatocytes as ex-vivo replacements or supports for endogenous liver function.
View Article and Find Full Text PDFResveratrol (RSV; trans-3,5,4'-trihydroxystilbene) strongly activates sirtuin 1, and it and its analogue V29 enhance the proliferation of mesenchymal stem/stromal cells (MSCs).Although culture medium containing 5-azacytydine and RSV inhibits senescence of adipose tissue-derived MSCs isolated from horses with metabolic syndrome, few studies have reported the effects of RSV on equine bone marrow-derived MSCs (eBMMSCs) isolated from horses without metabolic syndrome. The aim of this study was to investigate the effects of RSV and V29 on the cell cycle of eBMMSCs.
View Article and Find Full Text PDF