Developing and using a school menu healthiness assessment tool to analyse school food provision in Wales.

Objectives: To design and develop a new, innovative and valid School Menu Healthiness Assessment Tool that is suitable for the quantitative and qualitative analysis of school food and drink provision. Secondly, to analyse primary and secondary school menus and price lists pan-Wales to ascertain their healthiness and whether free school meal eligible pupils can afford to access healthy, nutritious food across the school day.

Design: Codable items and categories of school food and drink provision were operationalised before the tool underwent iterative development and testing.

The practical and ethical challenges of identifying, accessing and obtaining school canteen transactional data for public health research.

Objective: The purpose of the study was to investigate the feasibility of using existing data to better understand what pupils purchase during the school day and its nutritional quality. This report highlights the ethical challenges experienced in attempting to obtain anonymised school canteen transaction data for public health research.

Methods: Semi-structured interviews were conducted before a variety of approaches were tried to recruit secondary schools for the study via purposive sampling.

HLA class I antibody-activated endothelium promotes CD206+ M2-macrophage polarization and MMP9 secretion through TLR4 signaling and P-selectin in a model of antibody-mediated rejection and allograft vasculopathy.

HLA donor-specific antibodies (DSA) elicit alloimmune responses against the graft vasculature, leading to endothelial cell (EC) activation and monocyte infiltration during antibody-mediated rejection (AMR). AMR promotes chronic inflammation and remodeling, leading to thickening of the arterial intima termed transplant vasculopathy (TV) or cardiac allograft vasculopathy (CAV) in heart transplants. Intragraft-recipient macrophages serve as a diagnostic marker in AMR however, their polarization and function remain unclear.