Sodium valproate, a potential repurposed treatment for the neurodegeneration in Wolfram syndrome (TREATWOLFRAM): trial protocol for a pivotal multicentre, randomised double-blind controlled trial.

Introduction: Wolfram syndrome (Spectrum Disorder) is an ultra-rare monogenic form of progressive neurodegeneration and diabetes mellitus. In common with most rare diseases, there are no therapies to slow or stop disease progression. Sodium valproate, an anticonvulsant with neuroprotective properties, is anticipated to mediate its effect via alteration of cell cycle kinetics, increases in p21 expression levels and reduction in apoptosis and increase in Wolframin protein expression.

Antimicrobial Susceptibility of Isolates Causing Community-Acquired Urinary Tract Infections: Comparison of Methods.

Due to bacterial resistance to antimicrobials, antibiotic therapy for urinary tract infections (UTIs) has become a major challenge for clinicians. The present work aimed to compare the antimicrobial susceptibility profiles of 53 uropathogenic (UPEC) isolates, assessed using the disk diffusion method and two automated systems (PHOENIX BD™ and VITEK2), with interpretations based on CLSI and BrCAST guidelines. Twenty-five antibiotics were tested to assess differences in susceptibility profiles.

Sustainable care: How CSR shapes wellbeing in healthcare organizations in Beijing, Shanghai, and Guangzhou.

This article investigates the link between corporate social responsibility (CSR) perceptions of employees and employee burnout, from a sustainable development point of view, in the healthcare system of China. It fills the void in conventional literature by analyzing the indirect effect of CSR on the health and well-being of health workers aligning with SDGs focused on health and wellbeing. To be able to address the crux of healthcare professionals' burnout which can have far-reaching negative consequences for individual welfare and healthcare delivery, this research explores the linkages between CSR perceptions, employee burnout, happiness, psychological safety, and altruistic behavior.

Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Sleep Deprived Patients: A Systematic Review and Meta-analysis (P8-9.008).

Objective: To analyze whether cerebrospinal fluid (CSF) biomarkers, such as total tau (t-Tau), phosphorylated tau (p-Tau), and amyloid-β42 (Aβ42), increase with sleep deprivation (SD).

Background: Several studies have assessed CSF biomarkers associated with Alzheimer's disease (AD) that could increase with SD; however, the results remain conflicting.

Design/methods: We conducted a prognostic systematic review and meta-analysis of randomized and non-randomized studies evaluating SD of any type versus regular sleep patterns in patients without AD.

Ion release, cytocompatibility and microbial inhibition of a novel varnish containing fluoride-doped bioactive glass ceramics: an in vitro study.

Objectives: The study aimed to develop and evaluate in vitro a varnish containing fluoride-doped glass ceramics capable of inhibiting oral microorganisms, releasing hydroxyapatite-forming ions, and ensuring biocompatibility.

Materials And Methods: For the production of the experimental varnish (VE), composed of hydrogenated rosin, 10% and 20% by weight of glass ceramics with composition S53P4 (CF0) and doped with F- ions (CF5 and CF10) were incorporated. The EVs were characterized by Rheology, Scanning Electron Microscopy (SEM), FTIR, ion release (fluoride and calcium ions), cytotoxicity on VERO cells, and antimicrobial effect on S.