Publications by authors named "R G Costello"

Despite broad consensus that highlighting counter-stereotypical scientist role models in educational materials promotes equity and success, the specific elements that make these materials effective remain untested. Are pictures of counter-stereotypical scientists enough to communicate to students that scientists come from a variety of backgrounds, or is additional information required? To parse the effects of including visual depictions and humanizing information about scientists featured in biology course materials, we distributed three randomized versions of assignments over several academic terms across 36 undergraduate institutions ( > 3700 students). We found that including humanizing information about scientists was key to increasing student engagement with the biology course materials.

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Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have poor outcomes. Gemcitabine + oxaliplatin (GemOx) with rituximab, a standard salvage therapy, yields complete response (CR) rates of approximately 30% and median overall survival (OS) of 10-13 months. Patients with refractory disease fare worse, with a CR rate of 7% for subsequent therapies and median OS of 6 months.

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Background: Imatinib is the treatment of elderly or frail patients with chronic myeloid leukemia (CML). Trough levels of around 1000 ng/ml are considered as the target exposure.

Objectives: We searched for baseline parameters associated with imatinib pharmacokinetics, and studied the clinical impact of subsequent adaptive dosing.

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Article Synopsis
  • * These technologies pave the way for decentralized clinical trials, allowing for a more inclusive study population, reduced costs, and faster access to new treatments.
  • * The discussion includes the use of digital endpoints, different trial designs, a specific example of a fully decentralized asthma trial, and examines the pros and cons of these methods from various perspectives (clinicians, patients, and regulators).
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Featuring scientists in classroom materials provides opportunities for students to relate to scientists as role models and see themselves in science. However, it is unclear what information students find most relatable when encountering scientists throughout their education. In this study, we manipulated the amount and type of information provided about scientists featured in biology courses.

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