Publications by authors named "R G Carbone"
Current epidemiological data on interstitial lung disease (ILD) are still poor. The principal cause of the discordant data is associated with a heterogeneous group of respiratory diseases that includes a large number, about 200 families, with low frequency, distinct and sometimes unknown etiology, and different progression. In fact, some conditions spontaneously resolve, whereas others, such as IPF and most non-IPF ILDs, progress to respiratory failure and death despite treatment.
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- The study analyzes bacteremia and antibiotic resistance in Gram-negative bacilli among patients with hematological malignancies and those undergoing hematopoietic stem cell transplants across different geographic regions.
- It includes 1,277 cases of bacteremia, revealing that Gram-negative bacilli were present in 60.3% of episodes, with a notable occurrence of multidrug-resistant organisms (MDROs) affecting 40.2% of these infections.
- Key risk factors for 30-day mortality identified include relapse of underlying disease, use of corticosteroids, and the presence of resistant bacteria, emphasizing the high mortality associated with carbapenem-resistant cases.
Article Synopsis
- * The study proposed an innovative approach by integrating a specialized surface for better cell attachment, a FUCCI(CA)2 sensor, automated image analysis, and a custom machine learning algorithm, allowing accurate measurement of cell cycle phases in non-adherent cells.
- * The developed automated cell cycle analysis system was validated on leukemia cell lines and is compatible with both non-adherent and adherent cells, making it a valuable free tool for enhancing cancer research and drug development.
Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm.
Eur J Clin Microbiol Infect Dis
September 2024
Purpose: Data on short courses of antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients are limited. The aim of the study was to describe and compare the frequency of bacteremia relapse, 30-day overall and infection-related mortality, Clostridiodes difficile infection and length of hospital stay since bacteremia among those who received antibiotic therapy for 7 or 14 days.
Methods: This is a multicenter, prospective, observational cohort study in adult high-risk neutropenic patients with hematologic malignancies or hematopoietic stem cell transplant and monomicrobial Enterobacterales bacteremia.