A contemporary, multiinstitutional analysis of transcription factor lineage in pituitary adenomas: comparative study of neuroimaging, histopathology, and clinical outcomes.

Objective: Pituitary adenomas (PAs) are common lesions that often present with endocrinopathy and/or visual symptoms. Classification of PAs has historically been based on functional status and histopathological staining of anterior pituitary hormones. In 2017, the WHO revised the classification of PAs, establishing cell lineages identified by the transcription factors (TFs) PIT1, TPIT, and SF1.

Can ambulatory blood pressure biomarkers predict future falls amongst older people?

Background: While ambulatory blood pressure monitoring (ABPM) biomarkers can predict cardiovascular and cerebrovascular outcomes, little work to date has examined their link with falls. The objective of this study was to examine associations between ABPM biomarkers and further falls in a cohort of older people with recent falls.

Methods: A consecutive series (n = 118) of patients≥70 years undergoing falls assessment including 24-hour ABPM were recruited and followed to their next clinical appointment, where incident falls were recorded (minimum follow-up 1 month).

Consequences of the Crisis in Social Care for Older Hospital Inpatients with Frailty.

Aim: The social care system is currently under enormous pressure leading to delays in home care provision and unnecessarily prolonged hospital stays for frail, older people. This study examines the rate of hospital-associated complications (HAC) amongst older inpatients who are medically optimised but awaiting home care to facilitate discharge home.

Methods: Electronic records of patients =65 years with delayed transfer of care (DTOC) awaiting home care provision were examined for incidence of delirium, falls and infection (n=100).

Clinical and radiographic presentation and surgical outcomes of TPIT+ silent corticotroph pituitary neuroendocrine tumors: a multi-institutional experience and review of the literature.

Background: Accurate lineage identification of pituitary neuroendocrine tumors (PitNETs) is critical to inform our understanding of tumor biology and aggressiveness. While this was previously performed using immunohistochemistry for anterior pituitary hormones, the recent WHO update using lineage specific transcription factors (PIT-1, SF-1, TPIT) has led to improved classification of PitNETs. Although the identification of TPIT, a T-box pituitary transcription factor, has afforded improved classification of corticotroph PitNETs from what were previously thought to be null cell adenomas, the standardization of lineage specific transcription factor staining has yet to be fully adopted and as a result the clinical aggressivness and outcomes of these newly classified silent TPIT+ PitNETs has yet to be fully described.