Characterization of a continuous agitated cell reactor for oxygen dependent biocatalysis.

Biocatalytic oxidation reactions employing molecular oxygen as the electron acceptor are difficult to conduct in a continuous flow reactor because of the requirement for high oxygen transfer rates. In this paper, the oxidation of glucose to glucono-1,5-lactone by glucose oxidase was used as a model reaction to study a novel continuous agitated cell reactor (ACR). The ACR consists of ten cells interconnected by small channels.

Molecular characterization of enzalutamide-treated bone metastatic castration-resistant prostate cancer.

Background: Enzalutamide is a novel antiandrogen with proven efficacy in metastatic castration-resistant prostate cancer (mCRPC).

Objective: To evaluate enzalutamide's effects on cancer and on androgens in blood and bone marrow, and associate these with clinical observations.

Design, Setting, And Participants: In this prospective phase 2 study, 60 patients with bone mCRPC received enzalutamide 160mg orally daily and had transilial bone marrow biopsies before treatment and at 8 wk of treatment.

Prevention of early-onset Group B Streptococcal disease - the Northern Ireland experience.

Objectives: To ascertain guideline adherence for prevention of Group B Streptococcal (GBS) neonatal infection and establish prevalence and outcomes in Northern Ireland (NI).

Design: Retrospective observational study.

Setting: Northern Ireland maternity units.

Caesarean section in the second stage of labour: a retrospective review of obstetric setting and morbidity.

Caesarean section in the second stage of labour is a difficult procedure, with little published evidence to guide practice. We investigated the background and morbidity. Case notes of all emergency caesareans at full dilatation over 1 year in two hospitals were studied for demographics, grade of attending doctor, other methods of surgical delivery and morbidity.