Publications by authors named "R Fultz"
Dysbiosis of the gut microbiome is implicated in the growing burden of non-communicable chronic diseases, including neurodevelopmental disorders, and both preclinical and clinical studies highlight the potential for precision probiotic therapies in their prevention and treatment. Here, we present an optimized protocol for the preparation and administration of Limosilactobacillus reuteri MM4-1A (ATCC-PTA-6475) to adolescent mice. We also describe steps for performing downstream analysis of metataxonomic sequencing data with careful assessment of sex-specific effects on microbiome composition and structure.
View Article and Find Full Text PDFStudent instructional assistants (IAs) are an integral part of most students' college experience in higher education. When properly trained, IAs can improve students' grades, engagement with course content, persistence, and retention. Recently, the COVID-19 pandemic forced the transition of nearly all instructional practices online.
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- Maternal gut microbiome dysbiosis due to high-fat diet (MHFD) during pregnancy is linked to negative neurodevelopmental effects in offspring.
- A study found that female offspring from MHFD mice show reduced microbial diversity and social behavior issues, despite an initial recovery of their gut microbiota.
- Treatment with Limosilactobacillus reuteri enhances beneficial gut bacteria in these offspring, suggesting potential strategies for addressing neurodevelopmental disorders stemming from maternal diet.
Article Synopsis
- Gut microbes can make important chemicals that affect our brain and mood.
- Researchers studied these chemicals and discovered that certain microbes produce acids and other compounds that can change levels of brain-related substances in mice.
- The study shows that having specific gut microbes can change how much of these brain chemicals, like GABA, are found in the intestines, which might affect how we feel and think.