Effect of N-glycosylation on secretion, degradation and lipoprotein distribution of human serum amyloid A4.

Serum amyloid A (SAA) is a family of apolipoproteins predominantly synthesized and secreted by the liver. Human SAA4 is constitutively expressed and contains an N-glycosylation site that is not present in other SAA subtypes. SAA4 proteins are not fully glycosylated, resulting in the presence of both glycosylated and non-glycosylated forms in human plasma.

Advancement of Generative Pre-trained Transformer Chatbots in Answering Clinical Questions in the Practical Rhinoplasty Guideline.

Background: The Generative Pre-trained Transformer (GPT) series, which includes ChatGPT, is an artificial large language model that provides human-like text dialogue. This study aimed to evaluate the performance of artificial intelligence chatbots in answering clinical questions based on practical rhinoplasty guidelines.

Methods: Clinical questions (CQs) developed from the guidelines were used as question sources.

Evaluation of Interaction With Bio-absorbable Polyglycolic Acid Spacer and Anti-adhesive Agents Using a Rat Experimental Model.

Background/aim: Neskeep, an absorbable polyglycolic acid spacer, has been developed as the optimal material for spacer placement surgery. However, preventing its severe adhesion is a crucial concern. Therefore, we aimed to identify an effective anti-adhesion agent for Neskeep using rat models.

Spontaneous rupture of splenic hilar lymph node metastasis from hepatocellular carcinoma.

Spontaneous rupture of a primary hepatocellular carcinoma (HCC) is a frequently observed and fatal complication. However, the rupture of lymph node (LN) metastases from HCC is rare. A 79 year-old male with hepatitis B underwent three liver resections for HCC.